Find your Personal Dosage for Cannabis CBD Begin with a low dose and gradually increase as needed. Start with 2 drops under the tongue - hold for 1-3 minutes. Wait for 30 minutes - for the drops to take effect. Notice how well you feel - any changes in your symptoms. Repeat steps 1 - 3 - until you feel comfortable decrease in your symptoms. Keeping a journal is a great way to determine your perfect dosage.