Cannabis & Menopause Like any other natural transition, Menopause can cause uncomfortable changes. Hot flashes Cannabis THC Cannabinoid helps to regulate the body temperature. Sleep disturbances CBD influences the body's Serotonin System and can help improve the quality of sleep. Mood shifts Cannabis lowers depression and anxiety which are common during Menopause. Aches & joints pain Cannabidiol has anti-inflammatory properties that provide relief.